# Reading list

> The Premier Med Spa reading list — The Premier Med Spa reading list: Epitalon cell experiments, animal lifespan and cancer models, pineal cells and the observational Epithalamin human cohort.

The experimental cast, with the original paper titles.

## Cellular mechanisms

The [normal-cell and cancer-cell comparison](https://pubmed.ncbi.nlm.nih.gov/40908429/) opens the double bill. The [earlier fetal-fibroblast paper](https://pubmed.ncbi.nlm.nih.gov/12937682/) supplies the initial telomerase observation, while the [rat pineal-cell experiment](https://pubmed.ncbi.nlm.nih.gov/22816096/) concerns melatonin synthesis. The later comparison deserves top billing for me because it makes cellular identity impossible to overlook.

## Animals and people

The [female SHR mouse paper](https://pubmed.ncbi.nlm.nih.gov/14501183/) reports maximum and mean lifespan separately. The [fruit-fly paper](https://pubmed.ncbi.nlm.nih.gov/11087911/) concerns exposure during development; the [colon-carcinogenesis paper](https://pubmed.ncbi.nlm.nih.gov/12049808/) concerns a specific induced model in rats. The [human cohort](https://pubmed.ncbi.nlm.nih.gov/14523363/) studied Epithalamin-based preparations in elderly people and was observational.

## A broader account

The [Epitalon overview](https://pubmed.ncbi.nlm.nih.gov/40141333/) gathers the proposed mechanisms and notes limited physicochemical and structural investigation. I regard that acknowledged incompleteness as a useful companion to its optimistic title. The full citations follow.

## References

[1] Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity https://pubmed.ncbi.nlm.nih.gov/40908429/
[2] Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells https://pubmed.ncbi.nlm.nih.gov/12937682/
[3] Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice https://pubmed.ncbi.nlm.nih.gov/14501183/
[4] Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats https://pubmed.ncbi.nlm.nih.gov/12049808/
[5] Peptides of pineal gland and thymus prolong human life https://pubmed.ncbi.nlm.nih.gov/14523363/
[6] Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture https://pubmed.ncbi.nlm.nih.gov/22816096/
[7] Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties https://pubmed.ncbi.nlm.nih.gov/40141333/
[8] Effect of epitalon on the lifespan increase in Drosophila melanogaster https://pubmed.ncbi.nlm.nih.gov/11087911/

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At The Premier Med Spa I examine the cast of published research, from cells to human cohorts, as a reader running a publication rather than a business, and none of it is medical advice.