Reading list
The experimental cast, with the original paper titles.
Cellular mechanisms
The normal-cell and cancer-cell comparison opens the double bill. The earlier fetal-fibroblast paper supplies the initial telomerase observation, while the rat pineal-cell experiment concerns melatonin synthesis. The later comparison deserves top billing for me because it makes cellular identity impossible to overlook.
Animals and people
The female SHR mouse paper reports maximum and mean lifespan separately. The fruit-fly paper concerns exposure during development; the colon-carcinogenesis paper concerns a specific induced model in rats. The human cohort studied Epithalamin-based preparations in elderly people and was observational.
A broader account
The Epitalon overview gathers the proposed mechanisms and notes limited physicochemical and structural investigation. I regard that acknowledged incompleteness as a useful companion to its optimistic title. The full citations follow.
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity ↗
- Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells ↗
- Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice ↗
- Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats ↗
- Peptides of pineal gland and thymus prolong human life ↗
- Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture ↗
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties ↗
- Effect of epitalon on the lifespan increase in Drosophila melanogaster ↗